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POSTER NO: 172 Structure of congenital malformations in newborns in Moldova
E.A. Grigori, P.M. Stratulat, S.A. Groppa The study of structure of congenital malformations (CM) in newborns was been carried out on the basis of data the nation-wide Moldavian Congenital Anomalies Registry. The Moldavian population- based National Registry of Congenital Anomalies was established in 1989. It covers now 50000 births per year. It is a nation-wide registry which includes all births to Moldavian mothers. All births in Moldova take place in maternity-hospitals. The registration has been including livebirths (during the neonatal period) and stillbirths. The registration comprise 40 conditions and subconditions conform to EUROCAT code ICD-9 BPA, 27 minor anomalies, multiple anomalies and syndromes. Among 298792 newborns CM were revealed in 5643 cases - 1.89% and in 19.7% neonatal deaths (446 cases). The incidence of multiple anomalies was 15.6%. Among single ones of CM the most frequent was CM of systems musculoskeletal - 34.9% and cardiovascular - 17.9%; the CM of systems central nervous consist 9.2%, digestive - 9.2%, genital - 5.2%, respiratory - 0.5% internal urogenital CM - 1.5%. In neonatal deaths significantly increased incidence of multiple CM - 28.3% (p<0.001), malformations of central nervous system - 14.1% (p<0.01), digestive system - 15.7 (p<0.001), cardiovascular system - 20.4 (p<0.05). Thus, during period neonatal of life a considerable change of the structure of CM occurred. It was connected by elimination of neonates with nervous, digestive, multiple congenital defects. |